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Search Results - therapeutics+%3e+mirna
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MicroRNA mimics as potential differentiation agents for treating neuroblastoma
Neuroblastoma,themostcommonextracranialsolidtumorofchildhood,arisesfromneuralcrestcellprecursorsthatfailtodifferentiate.Inducingcelldifferentiationisanimportanttherapeuticstrategyforneuroblastoma.Wedevelopedadirectfunctionalhigh-‐contentscreentoidentifydifferentiation-‐inducingmicroRNAs,inordertodevelopmicroRNA-‐baseddifferentiationtherapyforneuroblastoma.WediscoverednovelmicroRNAs,andmorestrikingly,threemicroRNAseedfamiliesthatinduceneuroblastomacelldifferentiation.Inaddition,weshowedthatmicroRNAseedfamilieswereoverrepresentedintheidentifiedgroupoffourteendifferentiation-‐inducingmicroRNAs,suggestingthatmicroRNAseedfamiliesarefunctionallymoreimportantinneuroblastomadifferentiationthanmicroRNAswithuniquesequences.Wefurtherinvestigatedthedifferentiation-‐inducingfunctionofthemicroRNA-‐506-‐3p/microRNA-‐124-‐3pseedfamily,whichwasthemostpotentinducerofdifferentiation.Weshowedthatthedifferentiation-‐inducingfunctionofmicroRNA-‐506-‐3p/microRNA-‐124-‐3pismediated,atleastpartially,bydown-‐regulatingexpressionoftheirtargetsCDK4andSTAT3.WefurthershowedthatexpressionofmiR-‐506-‐3p,butnotmiR-‐124-‐3p,isdramaticallyup...
Published: 9/14/2023
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Inventor(s):
Liqin Du
,
Alexander Pertsemlidis
Keywords(s):
Category(s):
Clinical Specialty > Oncology
,
Clinical Specialty > Neurology
,
Therapeutics > miRNA