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Organ-on-Chip Apparatus for Quantitative Study of Cellular Interaction with Ultrasound

This is an organ-to-chip device that is constructed by using thin membranes. The device allows quantitative in vitro modeling of cellular interactions by using ultrasound. The technology also has a large potential for therapeutic applications for treating different diseases. The flexibility of organ-on-chip technologies is a great tool to help speed...

Published: 11/6/2024 | Inventor(s): Jian Gu, Adam Akkad, Frederic Zenhausern

Keywords(s):

Category(s): Technology Classifications > Research Tools > Simulators and Modeling Tools, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Life Sciences

Myelin Breakdown Products as Plasma Biomarkers of Therapeutic Efficacy in the Acute Phase after Stroke

This invention pertains to the use of myelin breakdown products, such as lipids indicative of brain lipid catabolism, as plasma biomarkers for the diagnosis and prognosis of ischemic stroke (IS). Researchers discovered an acute signature of brain lipid catabolism in the plasma 24 hours after a stroke in mouse model research. Notably, a substantial proportion...

Published: 8/12/2024 | Inventor(s): Kristian Doyle, Danielle Becktel

Keywords(s):

Category(s): Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Life Sciences > Biomarkers

Arachidonic Acid Derivatives as Plasma Biomarkers of Chronic Inflammation After Stroke

This invention pertains to the use of arachidonic acid derivatives as plasma indicators for the diagnosis and prognosis of inflammation, including chronic inflammation, following ischemic stroke (IS). Researchers have identified novel plasma biomarkers indicative of neurodegeneration and inflammation in a mouse model of stroke, with particular emphasis...

Published: 8/12/2024 | Inventor(s): Kristian Doyle, Danielle Becktel

Keywords(s):

Stroke Outcome Prediction Using Vascular Imaging Features and Machine Learning

This technology is a stroke outcome prediction method to determine patient outcomes and inform treatment decisions. The method utilizes machine learning models trained with patient-specific vascular imaging features, patient demographics, stroke severity scores and clinical history as predictors to forecast a 90-day functional outcome following an ischemic...

Published: 8/1/2024 | Inventor(s): Aditi Deshpande, Kaveh Laksari, Jordan Elliott, Pouya Tahsili-Fahadan

Keywords(s):

Category(s): Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences

Smart EVD System

This invention is a smart system for the collection of cerebrospinal fluid from an external ventricular drain (EVD) that can automatically adjust the height and intercranial pressure of a patient. The invention will use a cerebrospinal fluid (CSF) flow sensor, a way to determine the position of the patient and the collection vessel, and an actuator...

Published: 8/1/2024 | Inventor(s): Eniko Enikov, Jesse Skoch

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Category(s): Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Medical Devices

Optical and Acoustic Coupling Materials and Technologies

This invention describes materials and chemicals with novel, optimal optical and acoustic properties that enable or improve methods that require coupling of light and sound for biomedical and defense applications related to imaging and monitoring therapy. This invention overcomes current limitations by proposing optically and acoustically transparent...

Published: 11/16/2023 | Inventor(s): Russell Witte, Christopher Salinas, Eric Reichel

Keywords(s):

Category(s): Technology Classifications > Imaging & Optics > Medical Imaging, Technology Classifications > Research Tools, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences

Glycopeptide-Lipid Supramolecular Assembly

This invention provides an approach, including compositions and methods for delivering glycopeptides to biological cells. This is done using supramolecular assemblies made of glycopeptides and amphipathic molecules, which may be used to deliver therapeutics, including glycosylated hormones or their analogues, such as endomorphin, dermorphin, angiotensin,...

Published: 6/20/2024 | Inventor(s): Robin Polt, Michael Heien

Keywords(s):

Category(s): Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Healthcare Portfolios > Neurology

Neonatal Anorectal Tonometer with Disposable/Detachable Tip

This technology is a neonatal anorectal tonometer that involves a detachable, fluid-filled tip with a quick release system involving (magnet & plate) that connects the tip to a force sensor inside the handle of the device. This device can be used as a substitute for digital rectal exams. Background: Cauda Equina Syndrome (CES) occurs when the Cauda...

Published: 8/1/2024 | Inventor(s): Eniko Enikov

Keywords(s):

Category(s): Technology Classifications > Healthcare Portfolios > Emergency Medicine, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Sensors & Controls, Technology Classifications > Sensors & Controls > Motion & Force

Stroke Outcome Prediction using Vascular Imaging Features

This is a prediction method to determine the outcome of a stroke based on vascular images presented by the patient. This model predicts the 90-day functional outcome after ischemic stroke at a significantly higher accuracy than current models, to inform treatment decisions and patient selection. Machine learning models were employed and trained with...

Published: 8/1/2024 | Inventor(s): Kaveh Laksari, Aditi Deshpande, Jordan Elliott, Pouya Tahsili-Fahadan

Keywords(s):

Category(s): Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Life Sciences > Diagnostics

Method for Diagnosing to Enable Treatment of Overwhelmed Myelin Lipid Processing in the Brain After Stroke

This invention addresses and provides a solution to secondary neurodegeneration post-stroke.It was discovered that foam cells form within primary infarcts and areas of secondary neurodegeneration after stroke. This invention provides for a method of noninvasive imaging and assessment of fatty acid oxidation in the brain after stroke using radionuclide...

Published: 5/20/2024 | Inventor(s): Kristian Doyle

Keywords(s):

Category(s): Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Imaging & Optics > Medical Imaging, Technology Classifications > Life Sciences > Diagnostics

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