Search Results - research+area+%3e+neurology+and+neurosurgery

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A multimedia artificial intelligence method of deep learning for detection of stroke using patient facial video and voice
Software Description of Invention Stroke is a common cerebrovascular disease and is a leading cause of death in the US. The current best method for diagnosis of acute ischemic stroke is magnetic resonance imaging, which is expensive, limited by patient factors, and not readily available in all care settings. The typical stroke evaluation relies on...
Published: 4/2/2025   |   Inventor(s): Stephen Wong, Kelvin Wong, John Volpi, James Wang, Sharon Huang, Mingli Yu, Tongan Cai
Keywords(s):  
Category(s): Clinical Area > Neurology, Research Area > Neurology and Neurosurgery, Technology Classifications > Other
Neural/Glial Cell-Derived Nanoparticles to Restore Neural Function in Alzheimer’s Disease
Asset/Technology Type Therapeutic/Drug Delivery Agent Description of Invention The invention is an engineered biomimetic nanoparticle (NP) that integrates neural or glial cell membrane proteins into lipid-based nanoparticles (a.k.a. neurosomes). The integration of these neural/glial cell proteins within the NP shell enables precise targeting to...
Published: 4/11/2025   |   Inventor(s): Robert Krencik, Assaf Zinger, Ennio Tasciotti, Caroline Cvetkovic
Keywords(s):  
Category(s): Clinical Area > Neurology, Research Area > Neurology and Neurosurgery, Research Area > Nanomedicine, Technology Classifications > Therapeutic > Drug Delivery, Technology Classifications > Therapeutic > Nanovesicles
Modulating the AIBP-CAV1-VEGFR3 axis to treat lymphatic disorders
This invention is a method of promoting lymphangiogenesis in order to treat lymphatic disorders, namely lymphedema and Alzheimer’s disease (AD). VEGFC-induced VEGFR3 signaling is the major driver of lymphangiogenesis, however the distinct molecular mechanisms determining how VEGFR3 signaling controls lymphatic endothelial cell (LEC) fate remains...
Published: 3/12/2024   |   Inventor(s): Longhou Fang, Jun-dae Kim
Keywords(s):  
Category(s): Clinical Area > Metabolic Disease, Inflammation, and Immunology, Clinical Area > Neurology, Clinical Area > Cardiovascular, Research Area > Heart and Vascular, Research Area > Immunobiology and Inflammation, Research Area > Neurology and Neurosurgery, Technology Classifications > Therapeutic > Cell and Gene Therapies, Technology Classifications > Therapeutic > Small Molecules, Technology Classifications > Therapeutic > Biologics
A DNAzyme that targets the CAG repeat RNA in polyglutamine diseases
The invention is a synthetic single-stranded DNA molecule that functions as a specific RNA-cleaving DNA enzyme (or DNAzyme) as a potential therapeutic for the treatment of polyglutamine diseases. The binding arms of this synthetic DNAzyme are complementary to the CAG repeats found in the pathological expansion of CAG trinucleotide repeats in the translated...
Published: 12/24/2024   |   Inventor(s): Nan Zhang, Tetsuo Ashizawa
Keywords(s):  
Category(s): Clinical Area > Neurology, Research Area > Neurology and Neurosurgery, Technology Classifications > Therapeutic > Cell and Gene Therapies