Search Results - pharmaceuticals+%26+therapeutics+%3e+pharma%3a+infectious+disease

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Use of plasma-treated liquids to treat herpes keratitis
PAGE TITLEOverviewPAGE SUMMARY Drexel researchers have shown that non-thermal dielectric barrier discharge (DBD) plasma treatment is a viable method for reducing herpes simplex virus infection and replication without significantly affecting host cells, making it an ideal treatment for herpes keratitis of the cornea.APPLICATIONSTITLE: ApplicationsPreventing...
Published: 5/19/2022   |   Inventor(s): Jane Clifford, Oleg Alekseev, Kelly Donovan
Keywords(s):  
Category(s): Plasma, Pharmaceuticals & Therapeutics, Pharmaceuticals & Therapeutics > Pharma: Infectious Disease, Plasma > Plasma: Liquid Treatment
A Chimeric MSP-based Malaria Vaccine
PAGE TITLE A chimeric MSP-based malaria vaccine PAGE SUMMARY There are an estimated 200 million people infected with malaria annually, with an estimated 400,000-500,000 deaths, and 40% of the world’s population at risk of contracting the disease. While artemisinin and mosquito reduction are the current treatments, there are artemisinin-resistant...
Published: 7/22/2024   |   Inventor(s): James Burns
Keywords(s):  
Category(s): Pharmaceuticals & Therapeutics, Pharmaceuticals & Therapeutics > Pharma: Infectious Disease, Pharmaceuticals & Therapeutics > Pharma: Malaria
Novel cyclic peptides and methods using same
NCS UPLOADED THROUGH THE MARKETING PROJECT 09-1100 TO COMBINE 16-1930, 14-1731 & 09-1100 PAGE TITLE Cyclic Peptide Triazole Dual Site Inhibitors of HIV-1 Envelope gp120 Glycoproteins PAGE SUMMARY Globally, there are about 37 million people living with HIV/AIDS and 1.2 million died from AIDS-related illnesses in 2014. In the US, over...
Published: 8/1/2024   |   Inventor(s): Irwin Chaiken, Adel Ahmed
Keywords(s):  
Category(s): Pharmaceuticals & Therapeutics, Pharmaceuticals & Therapeutics > Pharma: Infectious Disease
Mechanism-based small-molecule parasite inhibitors
PAGE TITLESmall molecule inhibitors of Plasmodium falciparum for antimalarial therapyPAGE SUMMARY There are an estimated 200 million people infected with malaria annually, with an estimated 400,000-500,000 deaths, and 40% of the world’s population at risk of contracting the disease. While artemisinin and mosquito reduction are the current treatments,...
Published: 8/27/2024   |   Inventor(s): Lawrence Bergman, Akhil Vaidya, William Welsh, Sandhya Kortagere
Keywords(s):  
Category(s): Pharmaceuticals & Therapeutics, Pharmaceuticals & Therapeutics > Pharma: Infectious Disease, Pharmaceuticals & Therapeutics > Pharma: Malaria
ATM-dependent phosphorylation of Sp1 is involved in the cellular response to DNA damage and enhances cellular survival after DNA damage
PAGE TITLEOverview PAGE SUMMARY The present invention is related to the discovery that phosphorylation of SP1 (SEQ ID NO.: 2) at serine residue 101 (known herein as phosphoserine101 Sp1) is an important part of a cell's response to DNA damage. This phosphorylation event is important for subsequent Sp1 localization to a site of DNA damage and is correlated...
Published: 5/19/2022   |   Inventor(s): Jane Clifford, Crystal Kelly, Beatrix Olofsson
Keywords(s): Antibody, In-vitro diagnostics
Category(s): Pharmaceuticals & Therapeutics, Pharmaceuticals & Therapeutics > Pharma: Genome Engineering, Pharmaceuticals & Therapeutics > Pharma: Infectious Disease
Plasmodium liver stage antigens
PAGE TITLE Plasmodium liver stage antigens for malaria vaccine and diagnostics PAGE SUMMARY There are an estimated 200-300 million people infected with malaria annually, with a mortality rate of 1-3%, and 40% of the world’s population at risk of contracting the disease. While the RTS,S (Mosquirix, GSK) recombinant protein-based vaccine is...
Published: 7/22/2024   |   Inventor(s): Lawrence Bergman, Stefan Kappe, Patrick Duffy, Urszula Krzych, Donald Heppner, Vladislav Malkov, Alice Tarun, Jason Wendler, Igor Bacik
Keywords(s):  
Category(s): Pharmaceuticals & Therapeutics, Pharmaceuticals & Therapeutics > Pharma: Infectious Disease, Pharmaceuticals & Therapeutics > Pharma: Malaria
Use of cymanquine compounds as antimalarial agents
PAGE SUMMARY There are an estimated 200-300 million people infected with malaria annually, with a mortality rate of 1-3%, and 40% of the world’s population at risk of contracting the disease. While artemisinin and mosquito reduction are the current treatments, there are drug-resistant parasites emerging, underscoring the need for the next generation...
Published: 8/1/2024   |   Inventor(s): Lawrence Bergman, William Geiger, Kevin Lam
Keywords(s):  
Category(s): Pharmaceuticals & Therapeutics, Pharmaceuticals & Therapeutics > Pharma: Infectious Disease, Pharmaceuticals & Therapeutics > Pharma: Malaria
Compositions Useful for Treating Herpes Simplex Labialis and/or Herpes Esophagitis, and Methods Using Same
PAGE TITLEOverview PAGE SUMMARY The present invention relates generally to compositions and methods for treating diseases and disorders caused by herpes simplex virus type 1, including herpes simplex labialis or herpes esophagitis, in a subject. In certain embodiments, the compositions of the invention comprise an ATM inhibitor and an anti-herpetic...
Published: 5/19/2022   |   Inventor(s): Jane Clifford, Oleg Alekseev, William Donegan
Keywords(s):  
Category(s): Pharmaceuticals & Therapeutics, Pharmaceuticals & Therapeutics > Pharma: Infectious Disease
Drug development for prevention and degradation of pathogen biofilms
PAGE TITLE RelA Inhibitors for Degradation of Pathogenic Biofilms PAGE SUMMARY Pathogenic biofilms are multicellular bacterial organisms associated with over 80% of clinical infections and often emerge on medical implants. The ability of bacteria to grow in a biofilm allows for the coordinated communication among cells and the production of extracellular...
Published: 8/1/2024   |   Inventor(s): Garth Ehrlich, Hai-Feng (Frank) Ji, Donald Hall, Jaroslaw Krol, John Cahill
Keywords(s):  
Category(s): Pharmaceuticals & Therapeutics, Pharmaceuticals & Therapeutics > Pharma: Infectious Disease
Benzodiazepine compounds with antiflavivirus activity
PAGE TITLE Benzodiazepine compounds and screening assay for flavivirus antiviral therapeutics PAGE SUMMARY Researchers in the Baruch S. Blumberg Institute and Drexel’s Department of Microbiology & Immunology have developed an antiviral screening assay based on monitoring viral activation of host cell beta-interferon gene expression in...
Published: 7/23/2024   |   Inventor(s): Timothy Block, Jinhong Chang, Ju-Tao Guo, Andrea (andy) Cuconati
Keywords(s):  
Category(s): Pharmaceuticals & Therapeutics, Pharmaceuticals & Therapeutics > Pharma: Infectious Disease
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