Search Results - john+(jay)+schneekloth

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Decreasing enteric methane emission from cattle by inhibition of RNase P, a tRNA biogenesis enzyme
THE CHALLENGE The challenge in reducing enteric methane emissions from ruminant livestock lies not only in the biological complexity of the rumen ecosystem but also in the practical and economic barriers to deploying mitigation strategies at scale. While technologies such as 3-nitrooxypropanol additives, nitrate supplements, and selective breeding...
Published: 1/15/2026   |   Inventor(s): Biswarup Mukhopadhyay, Vaishnavi Sidharthan, John Schneekloth, Venkat Gopalan
Keywords(s):  
Category(s): Technology Classifications > Biotechnology, Technology Classifications > Veterinary Technologies
Small Molecule Anti-cancer Agents that Stabilize the MYC-G-Quadruplex
Abstract: The proto-oncogene c-Myc is deregulated and overexpressed in ~70% of all cancers. Thus, c-Myc is an attractive therapeutic target since disrupting c-Myc activity could be used as pan-chemotherapy. Beyond cancer, Myc is also a positive effector of tissue inflammation, and its function has been implicated in the pathophysiology of heart failure....
Published: 4/22/2025   |   Inventor(s): John (Jay) Schneekloth, Kenneth Felsenstein, John Simmons, Lindsey Saunders, Beverly Mock, Peter Gareiss, David Calabrese, Elena Leon
Keywords(s): C-MYC, G-Quadruplex (G4), MULTIPLE MYELOMA, Schneekloth
Category(s): Application > Therapeutics, Collaboration Sought > Licensing, Collaboration Sought > Collaboration, TherapeuticArea > Oncology