Search Results - -nanomedicine

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Nanopreparation for Co-Delivery of Drugs and siRNA
INV-13004 Background Overexpression of p‑glycoprotein (encoded by MDR1 gene) is often associated with multidrug-resistant cancer. This protein leads to drug resistance by the efflux of chemotherapeutic drugs from the cancerous cells. Small interfering RNA (siRNA), also known as post-transcriptional gene silencer, can suppress the expression of specific...
Published: 9/10/2024   |   Inventor(s): Vladimir Torchilin, Swati Biswas
Keywords(s): Delivery, Drug Delivery, Healthcare Innovation, Medical, Nanomedicine, Nanotechnology, Pharmaceutical Composition, Therapeutic
Category(s): -Nanotechnology, -Nanomedicine, -Pharmaceutical Composition, -Health, Technology Classifications > 1. Life Science > Therapeutics, Technology Classifications > 1. Life Science > Drug Delivery
Engineering Bacillus subtilis as a Versatile and Stable Platform for Production of Nanobodies
INV-20012 Background Nanobodies, are a novel class of therapeutic proteins based on single-domain antibody fragments. Due to their small size and unique structure, they have shown great potential as next generation biological drugs. Existing methods for producing these nanobodies have come with certain drawbacks. A common method for production...
Published: 9/10/2024   |   Inventor(s): Jiahe Li
Keywords(s): Antibody manufacturing, Drugs, Protein production, Therapeutic
Category(s): -Nanomedicine
Man 1-2 Man-PEGylated Derivative as a Tool for in vitro and in vivo Dendritic Cell Targeting
INV-1151 Background The immune system (IS) has a delicate equilibrium between its cells. The most important cells of the IS are the B lymphocytes (BL), macrophages (MO), and dendritic cells (DC), so-called antigen presenting cells (APC). They are the key-linkers between the innate and the adaptive immunity, which is a crucial factor that will lead...
Published: 9/10/2024   |   Inventor(s): Vladimir Torchilin, Tatiana Levchenko, Juan Pappalardo, Stefano Salmaso, Micaela Toniutti
Keywords(s): Cancer, Chemistry, COVID, Drug Delivery, Genome, Health, Healthcare Innovation, Medical, Nanomedicine, Research Tool
Category(s): -Health, -Nanomedicine, -Cancer, Technology Classifications > 1. Life Science > Therapeutics, Technology Classifications > 1. Life Science > Drug Delivery
Macrophage-Targeted Multi-Compartmental Delivery Systems
INV-1028 Background Macrophages are important immune cells in the body that regulate different biological processes involved in inflammatory and infectious diseases. Macrophages originate from the mononuclear phagocyte system (MPS) in the bone marrow. The MPS system comprises of monocytes and tissue, it matures into a larger phagocytic cell called...
Published: 9/10/2024   |   Inventor(s): Mansoor Amiji, Husain Attarwala, Shardool Jain, Mayur Kalariya
Keywords(s): Biotech, Breast Cancer, Cancer, Chemotherapy, Drug Delivery, Drugs, Health, Medical, Nanomedicine
Category(s): -Biomedical Materials, -Health, -Nanomedicine, -Cancer, Technology Classifications > 1. Life Science > Drug Delivery